Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway
Recent evidence indicates that skeletal muscle influences systemic aging, but little is known about the signaling pathways and muscle-released cytokines (myokines) responsible for this intertissue communication.Here, we show that muscle-specific overexpression B CALM of the transcription factor Mnt decreases age-related climbing defects and extends